Acute Ischemia: low oxygen conditions.

Allogeneic: involving or derived from individuals of the same species, but from a donor that is not also the recipient or genetically identical to the recipient; can be related or unrelated donor.

Autologous: originating from the recipient rather than from a separate donor.

eHSCs (enhanced hematopoietic stem cells): hematopoietic stem cells that have been pharmacologically modulated to achieve a desired biological effect.

Hematological malignancy: cancers that arise from the hematopoietic system, giving rise to malignancies of the bone marrow, blood, spleen and/or lymph nodes.

Hematopoietic: of, relating to, or involved in the formation of blood cells.

Hematopoietic reconstitution: reestablishment of the body’s ability to form new blood cells.

Hematopoietic stem cell transplantation: transplantation of multipotent hematopoietic stem cells or blood, usually derived from bone marrow, peripheral blood stem cells, or umbilical cord blood.

Homing: the migration of cells to a target tissue.

HSC (hematopoietic stem cell): a cell isolated from the blood, bone marrow or umbilical cord that can renew itself, can differentiate to a variety of specialized cells, can mobilize out of the bone marrow into circulating blood, and can undergo programmed cell death (apoptosis).

iPSCs (induced pluripotent stem cells): pluripotent stem cells artificially derived from non pluripotent cells, typically adult somatic cells.

Ischemia: restriction in oxygen supply with resultant damage or dysfunction of tissue.

Mobilized: induced out of a tissue niche.

Pluripotent: potential to differentiate into any of the three germ layers: endoderm, mesoderm or ectoderm.  Pluripotent stem cells can give rise to any fetal or adult cell type.

Progenitor cell: a cell that has a tendency to differentiate into a specific type of cell, but is more target-cell specific than a stem cell.

Regenerative medicine: the process of replacing or regenerating human cells, tissues or organs to restore or establish normal function.

Skeletal muscle: a form of striated muscle tissue existing under control of the somatic nervous system- i.e. it is voluntarily controlled. It is one of three major muscle types, the others being cardiac and smooth muscle.

Stem cell: biological cell found in all multicellular organisms, that can divide (through mitosis) and differentiate into diverse specialized cell types and can self-renew to produce more stem cells.