Our cell therapy product candidate pipeline is comprised of first-in-class cellular immunotherapies for cancer and autoimmune diseases. Our programs reflect our dedication and commitment to pioneering ground breaking science to address severe, life-threatening diseases where the unmet need is significant and the treatment options are limited.
| Program | Cell Type Functionality |
Target(s) | Indication(s) | Research | PreClin | Phase 1 | Phase 2 | Phase 3 | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| iPSC-derived Cell Products | |||||||||||||||||||||||||||||
| FT516 | iNK hnCD16 |
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| FT596 | iNK hnCD16 + IL15RF + CAR-19 |
CD19, CD20 | BCL, CLL ± CD20 mAb |
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| FT538 | iNK hnCD16 + IL15RF + CD38-KO |
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| FT576 | iNK hnCD16 + IL15RF + CD38-KO + CAR-BCMA |
BCMA, CD38 | MM ± CD38 mAb |
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| FT819 | iT CAR-19, TCR-KO |
CD19 | Hematology |
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| FT536 | iNK hnCD16 + IL15RF + CD38-KO + CAR-MICA/B |
MICA/B | Solid tumors ± mAb |
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| FT873 | iT hnCD16 + IL7RF + CAR-B7H3 |
B7H3 | Solid tumors ± mAb |
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| iPSC-derived Cell Products – Cancer Immunotherapy Collaborations | |||||||||||||||||||||||||||||
| FT555/ Janssen |
iNK hnCD16 + IL15RF + CD38-KO + CAR-GPRC5D |
GPRC5D, CD38 | MM ± CD38 mAb |
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| Janssen | iNK,iT | KLK2; undisclosed | 3 tumor targets |
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| FT825/Ono | iNK,iT | HER2; undisclosed | 2 tumor targets |
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iPSC-DERIVED CELL PRODUCTS
| Program | Indication | Phase |
|---|---|---|
| FT500 iNK Non-engineered |
Solid tumors + CPI | 1 |
| FT516 iNKhnCD16 |
AML | 1 |
| BCL + CD20 mAb | 1 | |
| Solid tumors + PD-L1 mAb | 1 | |
| FT596 iNK hnCD16 + IL15RF + CAR-19 |
BCL, CLL ± CD20 mAb | 1 |
| FT538 iNK hnCD16 + IL15RF + CD38-KO |
AML | 1 |
| MM + CD38 mAb | 1 | |
| Solid Tumors + mAb | 1 | |
| FT576 iNK hnCD16 + IL15RF + CD38-KO + CAR-BCMA |
MM ± CD38 mAb | 1 |
| FT819 iT CAR-19, TCR-KO |
Hematology | 1 |
| FT536 iNK,iT hnCD16 + IL15RF + CD38-KO + CAR-MICA/B |
Solid tumors ± mAb | 1 |
| FT873 iNK,iT hnCD16 + IL7RF + CAR-B7H3 |
Solid tumors ± mAb | Pre |
iPSC-DERIVED CELL PRODUCTS – CANCER IMMUNOTHERAPY COLLABORATIONS
| Program | Indication | Phase |
|---|---|---|
| FT555/Janssen iNK hnCD16 + IL15RF + CD38-KO + CAR-GPRC5D |
MM ± CD38 mAb | Preclinical |
| Janssen iNK/iT |
3 tumor targets | Preclinical |
| Ono Pharma iNK/iT |
2 tumor targets | Preclinical |
iPSC = induced pluripotent stem cell iNK = iPSC-derived NK Cell iT = iPSC-derived T cell mAb = monoclonal antibody CPI = checkpoint inhibitor hnCD16 = high affinity, non-cleavable CD16 Fc receptor IL15-RF = IL15 receptor fusion CD38-KO = CD38 knock-out CAR = chimeric antigen receptor TCR-KO = T-cell receptor knock-out AML = acute myelogenous leukemia BCL = B-cell lymphoma CLL = chronic lymphocytic leukemia MM = Multiple myeloma
